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Acanthamoeba species are known to cause serious eye infections, particularly keratitis, which can lead to significant vision impairment. The most common source of these infections is linked to the use of contaminated lens care solutions. When individuals use improper or inadequately disinfected solutions to clean or store contact lenses, Acanthamoeba can be introduced directly to the eye. This practice can allow the amoebae to adhere to the lens and transfer to the corneal surface, leading to infection.

While contaminated drinking water and swimming in freshwater lakes can pose risks for acquiring Acanthamoeba, these routes are less commonly associated with eye infections specifically. Although exposure to soil is another potential source of Acanthamoeba infection, it is usually not related to ocular infections, which are predominantly traced back to lens care practices. Thus, the use of contaminated lens care solution stands out as the primary and most relevant source associated with eye infections from Acanthamoeba species.