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Severe Schistosomiasis can lead to portal hypertension due to the accumulation of eggs in the liver and portal venous system. Schistosoma species, particularly Schistosoma mansoni and Schistosoma japonicum, can cause significant damage to the liver and its surrounding structures as a result of the host's immune response to the eggs. This immune response leads to granuloma formation, inflammation, and fibrosis in the liver, ultimately obstructing the portal circulation.

As a consequence of the obstructed blood flow through the portal vein, pressure builds up, resulting in portal hypertension. This can lead to various complications, including esophageal varices, which may rupture and cause life-threatening hemorrhage, as well as splenomegaly and ascites due to increased pressure in the blood vessels supplying the liver and spleen.

While other conditions listed could involve various health complications, they are not direct consequences of severe Schistosomiasis. Port hypertension is a well-established result of the chronic, severe infection caused by Schistosoma species, which specifically affects the liver and its blood supply.